Emergency Contraception (EC)

The main purpose of contraception (or birth control) is to prevent an unplanned pregnancy. Most methods of contraception enable sexually active couples to temporarily avoid pregnancy. Emergency contraception (or post-coital contraception) is used in preventing pregnancy after intercourse when standard contraceptives have failed, when no contraceptives were used at all or in cases of sexual assault. Emergency contraception is not considered an abortion. However, it is not recommended to be used as regular contraception. Emergency contraception is generally effective for birth control (75-90%), but effectiveness varies depending on the time of the woman’s menstrual cycle and the timing of the prior sexual activity.

Mechanism of actions – a single mechanism has not been established. EC methods are not abortifacient. Possible mechanisms are:
– Prevent or postpone ovulation.
– Causing genital tract to be hostile to sperm or blastocyst.
– Interferes with tubal transport.
– Preventing fertilisation (with IUD use).
– Blocking implantation (with IUD use).

Type of emergency contraception

1. Intrauterine Contraceptive Device (IUD or IUCD) – An IUD is a birth control device that is inserted into a woman’s uterus by a doctor

Insertion of copper IUD should not be more than five days after unprotected intercourse. This is suitable for those who desire long-term contraception. The placement has risks of pelvic infection and uterine injury, although these are quite rare. In a small group of women, long-term use of an IUD for birth control may cause certain side effects, such as heavy menstrual bleeding and painful menstrual cramps. It can be removed easily in the clinic if unsuitable.

This is the only method of EC that is effective after ovulation has taken place, therefore, making it the most effective method among all the emergency contraceptive choices and ideal for those who want long-term contraception.

2. Hormones pills:

A. Progesterone receptor modulator – the drug is ulipristal acetate, marketed as ella®.

It is given as 30 mg single oral dose, within 5 days (120 hours) after unprotected intercourse or contraceptive failure. This should be the hormonal emergency contraception of choice in view of the higher effectiveness and fewer side effects when compared to the levonorgestrel or combined hormonal contraception.

B. Progestogen-only emergency contraception – the hormone used is levonorgestrel. The dosage is 1.5 gm as a single dose. This is better than the divided dose of 0.75mg given 12 hours apart. Ideally, it should be taken within 72 hours of unprotected intercourse. Commercial brand available are Madonna, Postinor-2, Escapelle.

C. Combined hormonal contraception (Yuzpe regime) – each dose should consist of ethinyl oestradiol (EE) 100 mcg and levonorgestrel (LNG) 500 mcg. Two doses are required. There are no commercial brands available for this regimen. However, this can be made from a variety of available combined oral contraceptives pills in the market. The dosage sgould be taken within 72 hours of unprotected intercourse and repeat another dose in 12 hours.  This is the least effective among the oral pills.

The most effective EC method is the intrauterine device (IUD). The risk of pregnancy following placement of a copper IUD is 0.1%. For oral types, the most effective is ulipristal acetate, followed by the levonorgestrel. Data from trials comparing ulipristal acetate and levonorgestrel report respective pregnancy rates of 1.8% for ulipristal acetate versus 2.6% for levonorgestrel. However, it is important to take note that these are ideal situations and the failure rate is higher if oral EC is taken after ovulation or the  longer the interval between having unprotected intercourse and taking the EC. Higher body weight or BMI could also reduce the effectiveness of oral EC, particularly the levonorgestrel and Yutze regime.

Oral EC pills can be used more than once in a cycle. Repeated doses may result in more irregular bleeding and side effects. You should discuss this with your healthcare provider if you are planning to use this more than once in one cycle. In terms of contraindication, ulipristal should be avoided in women with severe asthma on oral steroids. Other than this, it is generally safe to use ulipristal and levonorgestrel in the majority of healthy women.

Disadvantages of Emergency Contraception

  • Not as effective as other forms of regular birth controls. 
  • Side effects include nausea, vomiting, headache, breast tenderness, bloated feeling and swelling of hands and feet. The side effects may be less with the ulipristal or levonorgestrel and more severe with the use of the combined oestrogen and progestogen formulation (Yutzpe regime).
  • Further contraception is required
  • Certain medications taken before or after the use of oral emergency contraception may reduce the efficacy – please discuss with your doctor regarding these drug interactions.

Following the use of EC, you should:

  • Use a barrier method until the next period.
  • If vomiting occurs within 3 hours of taking oral EC, a repeat dose should be given.
  • Talk to your health care provider regarding long-term contraception choices.
  • Seek medical advice if you experience unexpected side effects. Or if menses is delayed by more than seven days, or has abnormal flow, and you suspect that you may be pregnant.

Menses following administration of EC pills:

  • 75 to 90% menstruate within seven days (before or after) of their expected date of the next menses.
  • Menstrual bleeding will be late in the remaining 10 to 20%.

Disclaimer

This is for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. It is important for readers to seek proper medical advice when necessary. 

Myths and facts of combined oral contraceptive (COC) pills

Currently, there is a wide selection of contraceptive methods available to suit the various reproductive needs of couples. Despite these, there is still a huge unmet need with regards to contraception. There are 123 million women around the world who are not receptive to contraception. In the 2015 United Nations Population Fund (UNFPA) report, 15 million adolescent girls in developing countries gave birth and 13 million lacked access to contraceptives. WHO estimated that approximately 214 million women of reproductive age, in developing regions, who want to avoid pregnancy are not using a modern contraceptive method and between 2015 and 2019, almost half of all pregnancies were unintended.

The combined oral contraceptive (COC) pills are readily available in the markets and yet women avoid them due to their belief in the myths surrounding them. Following are some common myths regarding the combined oral contraception pills and the facts to dispel them.

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Pre-Pregnancy Care for Woman with Type 2 Diabetes Mellitus

Article contributed by Ms Yong Lai Mee

The prevalence of Type 2 Diabetes Mellitus (T2DM) among women in childbearing age is increasing. Pre-existing T2DM in pregnancy increased the risk of maternal and neonatal complications such as macrosomia big baby), miscarriage, stillbirth, eclampsia (high blood pressure and its complications), and preterm labour. The American College of Obstetricians and Gynaecologists and the American Diabetes Association emphasized the importance of achieving optimum diabetes control for promoting the well-being of maternal and reduced prenatal fetus and baby adverse outcomes. Below are some tips to achieve optimum pre pregnancy diabetes care.

Blood Glucose Control

  • Keep pre pregnancy HbA1C < 6.5% to avoid complications during pregnancy.
  • Fetal mortality rate increased 4 folds in those with HbA1C >6.6%.
  • Poorly controlled pre pregnancy diabetes increases congenital heart diseases by 3 folds, neural tube defects increase by 4 folds and spontaneous miscarriages in 30-60% of all pregnancies.
  • Plan 4-6 months before pregnancy to ensure diabetes control is within target range.

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How Pregnancy Affects the Feet

Article contributed by Ms Emily Mah

For every pregnancy journey, a mother or mother-to-be naturally experiences feelings of excitement and apprehension. In this 40-week period, a woman’s body goes through so many phases of change. Visible changes of increasing waistline and digits on the weighing scale are often coupled with swelling in the ankles and the presence of stretch marks. Internal observations will show pregnancy’s effects on metabolism, respiration, bone density, and the digestive system, to name a few.

As the body accommodates a nurturing and developing fetus, stark changes in the anatomy and physiology of a woman will occur. Throughout the course of these 9 months, such changes actually have an impact on every organ system in the body.

In this article, we will cover how pregnancy affects the feet. Swelling is a common occurrence during this phase. Also known as oedema, swelling can occur in different parts of the body though it largely occurs in the ankle region. Puffiness in the face or the hands is occasionally present. Dark spider veins, also known as varicose veins, often cause aesthetic concerns in women. Pregnancy is presumed to be a major contributing factor in its increased prevalence. Aside from its undesirable sight, this can also lead to cramps, heaviness, aching or numbness in the feet and calves.

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Heartburn during pregnancy

Heartburn is a term used to describe a burning pain or discomfort in the chest and upper abdomen. The actual medical term for it is gastro-esophageal reflux disease (GERD). It is quite common for pregnant women to experience the symptoms of heartburn, which usually come and go until delivery. It can start anytime during the pregnancy period and may worsen as the pregnancy progresses (second or third trimester). While it can be uncomfortable or painful, heartburn by itself will not harm the baby.

Symptoms and signs

  • Burning pain in the center of the chest and the upper abdomen, frequently accompanied by an unpleasant taste in the mouth.
  • Belching (burping).
  • Nausea with or without vomiting.
  • Persistent throat irritation, with or without irritating dry cough.

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Ectopic pregnancy

Ectopic pregnancy is one that develops outside the uterus. The egg (oocyte) and the sperm meet in the fallopian tube and fertilization occurs. The embryo is supposed to move back to the uterine cavity for implantation. However, in ectopic pregnancy this does not occur, and the embryo gets implanted elsewhere. The most common location is in one of the narrow tubes that connect each ovary to the uterus (fallopian tube). As the fertilized egg enlarges, the fallopian tube stretches and ruptures, causing life-threatening internal bleeding. Other locations include the ovary, cervix, space beside the uterus (broad ligament space) or in the abdominal cavity. About 1 in 100 pregnancies is an ectopic.

CAUSES AND RISK FACTORS

The occurrence of ectopic pregnancy is usually associated with an abnormal function of the fallopian tubes. Hence, tubal pregnancy is the most common type. Hormonal imbalances or abnormal development of the fertilized egg might also play a role. Certain condition may predispose to a higher chance of ectopic pregnancy such as:

  • Previous abdominal or pelvic infection
  • Pelvic inflammatory disease (PID), involving the fallopian tubes
  • Pregnancy after tubal ligation
  • Assisted reproduction techniques such as in vitro fertilization.
  • Adhesions (bands of scar tissue) from previous pelvic surgery.
  • Previous tubal pregnancy.
  • History of endometritis (infection of the inner uterine lining)
  • Malformed (abnormal) uterus or fallopian tubes
  • Pregnant with an intrauterine device (IUD) in place (failure of IUD)

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COVID-19 and Pregnancy

We are now faced with an unprecedented pandemic due to the coronavirus. The COVID-19 is a new strain that has not been previously identified in humans. Those infected may take up to 14 days to develop symptoms. The main mode of transmission is mainly through respiratory droplets and close contacts. It may be possible that a person can get COVID-19 by touching a surface or object that has the virus on it and then touching their own mouth, nose, or possibly their eyes, but this is not thought to be the main way the virus spreads. Routes of transmissions such as fecal-oral, in-utero from mother to baby and others are not confirmed yet. Some infected persons may be asymptomatic and they potentially can pass along the infection to others. However, this is less common. For more information about coronavirus, click here and here

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